12BIS1012013TranslatLect12

Special bacterial protein synthesis initiates with

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Unformatted text preview: acid will fit into the peptidyl site (P-site) of the large (50S) subunit. Elongation: The mRNA is read on the ribosome in the 5' to 3' direction. The amino acid in the P site of the large subunit (50S) is transferred to the amino acid in the A site on the same subunit through the formation of a peptide bond. This complex is then transferred back to the P site. complex Termination: The codons, UAA, UAG and UGA (nonsense codons), together with releasing factors, terminate protein synthesis. Nonsense or stop codons do not bond to tRNAs, but rather they are bound by release factors RF1 and RF2. RF1 recognizes the UAA and UAG codon while the RF2 recognized the UAA and UGA codons. recognized BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 41 Translation Pre-Initiation and Initiation Complex BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 42 Translation Initiatio...
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