12BIS1012013TranslatLect12

Transfer wobble hypothesis explains how there are

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Unformatted text preview: ransfer RNAs (tRNAs) and aminoacyl synthetases (AAS). transfer Wobble Hypothesis explains how there are more than 20 but less ant 61 tRNAs for translation. for Chemical modifications of tRNAs makes them recognizable by initiation factors and the second adaptor molecule, aminoacyl synthetase. and Release factors recognize “stop codons” to terminate translation elongation. “stop BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 2 Translation Genetic Code Genetic and Protein Synthesis BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 3 Introduction ­ ­ One of the greatest challenges facing molecular biologists in One the 50's and 60's was determining the mechanism by which the "two great polymer languages" (i.e., nucleic acids and proteins) communicated with each other. This was an especially difficult problem because: This q q ­ (1) free nucleotides and amino acids have no strong affinity for each (1) amino other, (2...
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This note was uploaded on 02/12/2014 for the course BIS 101 taught by Professor Simonchan during the Spring '08 term at UC Davis.

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