15BIS101F2013MutatLect15

Lrodriguez 2013

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Unformatted text preview: ell Cycle Restart Death and Elimination Death of Damaged Cells of Cellular and Genomic Stability Cellular BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez 9 Summary of p53 Mutations Nonsense CGATGA ArgStop p53 DNA binding protein Missense CGGTGG ArgTrp Frameshift CGACTGA ArgXXX BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez 10 Molecular Basis of Mutation (Cause and Effect) Effects on gene expression BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez 11 Effects of Various Point Mutations Wild Type Gene Sequence Position DNA 123 5’ T T T 3’ A A A RNA 5’ U U U Amino acid Phe 456 789 TGT TAC 10 11 12 GTT 13 14 15 AGG ACA UGU Cys C G T A ATG UAC Tyr AA UU Val CC GG Glu Silent Mutation Position DNA 123 5’ T T C 3’ A A G RNA 5’ U U C Amino acid Phe 4 5 6 7 8 9 10 11 12 TGT TAC G T T 13 14 15 AGG ACA UGU Cys T A ATG UAC Tyr C G AA UU Val BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez CC GG Glu 12 Effects of Various Point Mutations Effects Wild Type Gene Sequence Wild Position DNA 123 5’ T T T 3’ A A A RNA 5’ U U U Amino acid Phe 456 789 TGT TAC 10 11 12 GTT 13 14 15 GAG ACA UGU Cys C G C G ATG UAC Tyr AA UU Val TC AG Glu Nonsense Mutation #1 Position DNA 123 5’ T T T 3’ A A A RNA 5’ U U U Amino acid Phe 4 5 6 7 8 9 10 11 12 TGA TAC G T T 13 14 15 GAG ACT UGA Non Non C G ATG UAC — C G A U — A U BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez T A — C G 13 Effects of Various Point Mutations Effects Wild Type Gene Sequence Wild Position DNA 123 5’ T T T 3’ A A A RNA 5’ U U U Amino acid Phe 456 789 TGT TAC 10 11 12 GTT 13 14 15 GAG ACA UGU Cys C G C G ATG UAC Tyr AA UU Val TC AG Glu Nonsense Mutation #2 Position DNA 123 5’ T T T 3’ A A A RNA 5’ U U U Amino acid Phe 456 789 TGT TAA 10 11 12 GTT 13 14 15 GAG ACA UGU Cys C G C G ATT UAA Non Non A U — A U BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez T A — C G 14 Effects of Various Point Mutations Effects Wild Type Gene Sequence Wild Position DNA 123 5’ T T T 3’ A A A RNA 5’ U U U Amino acid Phe 456 789 TGT TAC 10 11 12 GTT 13 14 15 GAG ACA UGU Cys C G C G ATG UAC Tyr AA UU Val TC AG Glu Missense Mutation Position DNA 123 5’ T T T 3’ A A A RNA 5’ U U U Amino acid Phe 4 5 6 7 8 9 10 11 12 TGT CAC G T T 13 14 15 GAG ACA UGU Cys C G GTG CAC His His C G AA UU Val BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression R.L. Rodriguez TC AG Glu 15 Effects of Various Point Mutations Effects Wild Type Gene Sequence Wild Position DNA 123 5’ T T T 3’ A A A RNA 5’ U U U Amino acid Phe 456 789 TGT TAC 10 11 12 GTT 13 14 15...
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This note was uploaded on 02/12/2014 for the course BIS 101 taught by Professor Simonchan during the Spring '08 term at UC Davis.

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