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Chapter+12+ Muscle Physiology

Chapter+12+ Muscle Physiology - Chapter 12 Muscle...

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Chapter 12 Muscle Physiology Chapter Outline Presynaptic modulation is different because it is before synapse and it affects the synapse. Talking about axoaxonic what it does determines on what accepts it and how it acts. Sympathetic and parasympathetic – varicosity Sympathetic- norepi or epi . Receptor is ???? Parasympathetic- varicosity, ca coming in, what type of neurotransmitter??? Acetyl choline. What type of receptor? Collenergic G PROTEINS they are all slow. Muscurinic. What will reup it? Acetyl cholinesterase Neuromuscular? Releases what? is the most common How are they alike how different? Can you sketch? What kind of receptors? Similarities differences, process etc. IT IS CRITICAL THAT YOU VIEW THE CD BEFORE COMING TO CLASS!! Be sure you know the following: Skeletal Muscle Structure The Mechanism of Force Generation in Muscle The Mechanics of Skeletal Muscle Contraction Types of Skeletal Muscle Fibers Smooth and Cardiac Muscle Classification of Muscle Skeletal muscle Smooth muscle Cardiac muscle Structure of a Skeletal Muscle Muscle = group of fascicles Muscle fibers extend length of muscle from tendon to tendon Components of a Muscle Fiber Muscle fibers surrounded by connective tissue Sarcolemma = plasma membrane Multinucleated Sarcoplasm = cytoplasm Components of a Muscle Fiber Contains many myofibrils Sarcoplasmic reticulum = smooth ER Contains many mitochondria- high energy Transverse tubules = T tubules ( from the side they look like Structure of a Skeletal Muscle Fiber fig 12.2 Myofibrils
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Myofibrils give skeletal/cardiac muscle striated appearance Orderly arrangement of thick and thin filaments Actin Myosin Striations due to thick and thin filaments which run parallel to long axis Filaments form sarcomeres Sarcomere(smallest acting unit) Structure fig 12.3 A band - dark striations, thick filaments I band - light striations, thin filaments only, no overlap ONLY ACTIN no myosin H zone - thick only, no overlap. Center only myocin M line is link for filaments it is in the center inbetween z lines Sarcomere Structure fig 12.5 Structure of a Thin Filament 3 Proteins in thin filaments Actin* Tropomyosin* Troponin* Actin has binding sites for myosin Figure 12.4 black part is binding site. Tropomyosin covers binding sites. Tropomyocin hook (3 molecule) troponin Actin Each G actin has a binding site for myosin Tropomyosin Overlaps binding sites on actin for myosin Troponin Regulatory protein Complex of three proteins Attaches to actin Attaches to tropomyosin Binds calcium reversibly- lets it go, not permanent. When Ca binds to troponin, troponin lifts tropomyosin off site and will expose those binding sites.
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