n engl j med 1996 abuzzahab et al n engl j med 2003

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Unformatted text preview: et al. (2011) Development Genotype! Environmental factors! IGF signaling! Phenotype" Physical Chemical Biological Insulin ­like Growth Factor ­1 (IGF ­1) P Q G A R R S A C D R C C L B ­domain C G F A G T D ­domain S K R R V D F K L A ­domain L N A E A L Y L Q F P M Y E K P L S E T Y P D E G T V P S C ­domain I G S F G A C V R C G D The IGF signaling is a evolutionarily conserved pathway  that plays fundamental roles in growth regulation Woods et al., N Engl J Med, 1996 Abuzzahab et al., N Engl J Med, 2003 Sutter et al., Science, 2007" Walenkamp et al., Liu et al., Cell, 1993 JCEM, 2005 Baker et al., Cell, 1993 Control Caldwell et al., Current Biology, 2005 Mirth et al., Current Biology, 2005 IGF-IR deficient Duan et al., PNAS 1999; Schlueter et al., FASEB J, 2006 Insulin ­like Growth Factor (IGF) Signaling: IGF ­1 IGF1R IGF ­2 IGF binding proteins (IGFBPs) Biological ac8ons IGFBP-1 is a hypoxia-induci...
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