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Unformatted text preview: relatively mild and patchy. His retrograde amnesia had regressed mainly to affect a 6 month period
before the injury. On other cognitive tasks, he performed at an average or above average level, and there
was no neuropsychological evidence of frontal lobe dysfunction. Neuroradiological investigations at various
stages after his injury failed to demonstrate a lesion in any of the thalamic nuclei. Magnetic resonance
imaging showed a lesion in the hypothalamus in the region of the mamillary bodies. Our study demonstrates
that marked, relatively focal, memory disorder after diencephalic injury can occur without direct pathology
to the body of the thalamus. It also indicates that structures in or adjacent to the hypothalamus, such as
the mamillary bodies, may play a more important role in human memory functioning than has hitherto
been considered. Mammillary bodies:
gone! (normally give rise
to massive projection to
the medial thalamus) INTRODUCTION c
B.J.'s pattern of memory There is s ontinuinhe debatel remporalglobe and diencephalothates been temorbydisordersd. although we have
disorder was strikingly th e neuroanatomican bav shown my t fN.A.,
similar to l hasi of m he os avoure
Structure within t media t
obviously not been able to administer which afull range oftomemory emory functioning. N.A. has performed over
candidates for those the re critically related human m tasks which In the
diencephalon, th thalamu has been he ubject o a numbe we human and B.J.
the years since his injury in 1960,e and a s number tof stests f which r of gave to animal have only been
investigations concerne with learning, a
ide variet of cerebra pathologies hav
developed and published in thed past fewdayears. The ntdfa rwmediatingymnemonic l rocesses (Kapurewhich B.J.
implicate the thalamus s being importan focal verbal memory deficit ,
displayed is as severe as thatnefound ost notable case studies in this respect has beensyndrome,t N.A. contrasts with the
1988). O of the m in patients with the amnesic that of patien and
(Teuber et on corresponding penetrating p memory tasks.
normal or m...
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- Fall '08