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Patient na and the mediodorsal thalamic nucleus

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Unformatted text preview: , entorhinal cortex; PH, parahippocampal cortex (dark yellow); Por, postrhinal cortex; PR, perirhinal cortex. Patient N.A. and the mediodorsal thalamic nucleus • Miniature fencing foil entered brain through right nostril and destroyed left dorsal thalamus, mammillary bodies; • Limited retrograde amnesia; marked anterograde amnesia for declarative information; • Temporal lobe systems plus midline thalamic – prefrontal systems involved in declarative information processing N.A. (born July 9, 1938), a young American airman, was injured on December 15, 1960, while stationed at the Azores. The injury resulted from a mock duel with another serviceman, when a miniature fencing foil entered the patient’s right nostril and punctured the base of the brain, after taking an obliquely upward course, slightly to the left. Brain (1990), 113, 1695-1706 THE ROLE OF D IENCEPHALI C PATHOLOGY IN HUMAN MEMORY DISORDER EVIDENC E F RO M A P ENETRATIN G P ARANASA L B RAI N I NJUR Y by H . D USOIR, 1 N . K APUR, 2 D. P . B YRNES, 1 S. M CKINSTRY 1 R. D. H OARE 3 and (From the xRoyal Victoria Hospital, Belfast, the 2Wessex Neurological Centre, Southampton, and the 3 Churchill Clinic, London, UK) B.J. was 27 yrs old when he sustained a penetrating head injury on October 4, 1986, this injury taking place in England. During a game of snooker, a brawl SUMMAR Y and in the ensuing disturbance a snooker developed H penetratin O RS A patient (B.J. cue was pushed up his left nostril.) is reported who developed severe memory impairment following .a D USOI R A NgDbraiTnH Einjury caused by a snooker cue which entered through his left nostril into the basal regions of the brain. Initially, his memory disorder had the clinical features of a dense amnesic syndrome, with both anterograde and retrograde amnesia, but B.J. subsequently showed significant recovery of memory function. Formal memory testing was carried out 21 months after injury. This demonstrated marked verbal memory impairment, as severe as that seen in patients with the amnesic syndrome. On nonverbal memory tests, his impairment was...
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