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G dont recall where i was on 911 dont recall where i

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Unformatted text preview: ery Accident Stroke Anterograde amnesia Present and future Retrograde: e.g., don’t recall where I was on 9/11; don’t recall where I was born, or the name of my parents Anterograde: cannot commit new information to memory. “Every day is alone in itself, whatever enjoyment I’ve had, and whatever sorrow I’ve had” Patient H.M. Residual capacities of H.M. • Learned and improved his performance in a mirrortracing task • However: could not recall training episodes or having experienced the task • Amnesia for declarative (facts) but not procedural (perceptual, motor) information Taxonomy of memory I. So… • Why did Lashley fail to find effects of large lesions on memory in rats, while destruction of just the hippocampus and surrounding cortex suffices in yielding complete anterograde amnesia in primates? ! • because he searched for the circuits of procedural memory in regions mediating memory for declarative information…. Taxonomy of memory II. *Priming: implicit memory about a stimulus that can later affect recall selection Patient K.C. - complete retrograde amnesia for episodic memory • Patient K.C.: frontoparietal damage (motorcycle accident):Magnetic resonance imaging (MRI) performed in 1996 revealed a pattern of diffuse brain damage that includes almost complete loss of hippocampal tissue and clear signs of atrophy to the parahippocampus in both hemispheres (see Rosenbaum et al., 2005). Also of note is a large lesion in left occipital–temporal cortex, which extends into retrosplenial cortex, as well as lesions to medial occipital– temporal–parietal, medial occipital, and left frontal–parietal regions. Other limbic structures such as the mammillary bodies, the septal area, and the fornices are also noticeably atrophic. • In addition to anterograde amnesia, similar to H.M., - and presumably reflecting the damage in the temporal lobe - K.C. has a complete retrograde amnesia for biographical information. This latter aspect differs from the more restricted retrograde amnesia in H.M. and likely reflects the massive loss of cortical tissue, the likely storage site of such information and the associated attribute space. Brain regions involved in different kinds of memory: Overview *Priming: implicit memory abo...
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