Lecture+Nov+12+rough+draft

Removal of amygdala hippocampus and surrounding

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ut a stimulus that can later affect recall selection What is responsible: hippocampus or amygdala, or both, or what? •removal of amygdala, hippocampus, and surrounding temporal lobe cortex; •Patients R.B.: selective CA1 damage after cardiac arrest: memory impairment, but limited severity •additional damage to adjacent cortical regions greatly exacerbates the memory impairment •also: later scans like this one showed cortical thinning and subcortical atrophy, infarcts Memory systems: medial temporal lobe and declarative memory • Delayed non-matching to sample performance impaired by temporal lobe lesions Memory systems: medial temporal lobe and declarative memory Conclusion: Processing of declarative information in the temporal lobe is necessary for memory formation. a Subicular complex Principles of memory systems as reflected by H.M.’s lesion and neuroanatomy CA1 CA3 Hippocampus Dentate gyrus Other direct projections Schematic view of the medial temporal lobe memory system for declarative memory, which is composed of the hippocampus and the perirhinal, entorhinal, and parahippocampal cortices. In addition to the connections shown here, there are also weak projections from the perirhinal and parahippocampal cortices to the CA1subiculum border. ! Entorhinal cortex (EC) Perirhinal cortex (PR) Parahippocampal cortex (PH) Unimodal and polymodal association areas (frontal, temporal, and parietal lobes) ! b PR PR EC EC EC EC PR PR PH PH Human Monkey Por Por Postrhinal cortex PR EC Rat (b) Ventral view of a human brain (upper left), monkey brain (upper right), and a lateral view of a rat brain (lower center). The major cortical components of the medial temporal lobe are highlighted and outlined. The hippocampus is not visible from the surface and in the human lies beneath the cortex of the medial temporal lobe. Its anterior extent lies below the posterior entorhinal (red ) and perirhinal ( purple) cortices, and the main body of the hippocampus lies beneath the parahippocampal cortex. In the rat, the parahippocampal cortex is termed postrhinal cortex. Abbreviations: EC...
View Full Document

Ask a homework question - tutors are online