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120910 Oncology 401 Lecture 3 - Oncology 401 Lecture 2...

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Oncology 401 Lecture 2 continued
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Causes of changes Genetic Epigenetic (Changes in modification state of the chromatin, leading to changes in transcriptional activity of genes)
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Epigenetic Modification of Histones Sharma S et al. Carcinogenesis 2009;31:27-36
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Epigenetic Modification of DNA Sharma S et al. Carcinogenesis 2009;31:27-36
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Changes in Patterns of Gene Expression Expands as the Neoplasia Progresses to a Worse Phenotype Expanding cascade of gene expression changes associated with transitions between normal cervix, early precancerous lesions CIN1/2, late CIN3 lesions, and malignant cervical cancer. 2000 0 1600 1200 800 400 Nnumber of di erentially expressed genes Transitions C I N 3 t o c a n c e r C I N 1 / 2 t o C I N 3 n o r m a l t o C I N 1 / 2 Fig. 2.1 - Expanding cascade of gene expre Ahlquist and colleagues, unpublished date
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Lecture 2: Summary Tumorigenesis is a disease that is progressive in nature Benign lesions show evidence for hyperplasia, dysplasia
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