120910 Oncology 401 Lecture 3

120910 Oncology 401 Lecture 3

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Unformatted text preview: Biological Carcinogens: Viruses and Other Pathogens Viruses cause ~20% of human cancer Human Cance ses cause approximately 15% of Hepatitis B Virus: hepatocellular carcinoma Hepatitis C Virus: hepatocellular carcinoma Epstein Barr Virus: Burkitts Lymphoma B cell lymphomas nasopharyngeal carcinoma gastric carcinoma • • • Kaposi Sarcoma­assoc Herpesvirus: kaposi’s sarcoma primary effussion lymphoma • Merkel Cell Carcinoma Polyomavirus: merkel cell carcinoma • Human Papillomavirus: cervical cancer anal cancer vaginal cancer penile cancer head/neck carcinoma Human T cell Lymphoma virus: adult T cell lymphoma • • Other Biological Carcinogens (5% of Human cancer) • • Helicobacter Pylori: gastric cancer Helminths (worms: Schistosoma haematobium, Opistorchis viverrini, and Clonorchis sinensis): bladder carcinoma, liver cholangiocarcinoma Summary Lecture 3 • • • • Environmental carcinogens contribute to a large fraction of human cancers, and often are avoidable. Chemicals are often activated to the ‘immediate’ carcinogens through metabolism in the liver or other organs. Chemical carcinogens often cause mutations Physical carcinogens (UV, radiation, X-...
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This document was uploaded on 02/14/2014.

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