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Unformatted text preview: Biological Carcinogens: Viruses and
Other Pathogens Viruses cause ~20% of human cancer Human Cance
ses cause approximately 15% of
Hepatitis B Virus: hepatocellular carcinoma Hepatitis C Virus: hepatocellular carcinoma Epstein Barr Virus: Burkitts Lymphoma
B cell lymphomas
gastric carcinoma • • • Kaposi Sarcomaassoc Herpesvirus: kaposi’s sarcoma primary effussion lymphoma •
Merkel Cell Carcinoma Polyomavirus: merkel cell carcinoma
• Human Papillomavirus: cervical cancer
head/neck carcinoma Human T cell Lymphoma virus: adult T cell lymphoma • • Other Biological Carcinogens
(5% of Human cancer)
• Helicobacter Pylori: gastric cancer
Helminths (worms: Schistosoma
haematobium, Opistorchis viverrini,
and Clonorchis sinensis): bladder
carcinoma, liver cholangiocarcinoma Summary Lecture 3
• • • • Environmental carcinogens contribute to a
large fraction of human cancers, and often
Chemicals are often activated to the
‘immediate’ carcinogens through
metabolism in the liver or other organs.
Chemical carcinogens often cause
Physical carcinogens (UV, radiation, X-...
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This document was uploaded on 02/14/2014.
- Fall '14