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Unformatted text preview: er (rare) Ahlquist and colleagues, unpublished date Lecture 2: Summary
• • • • Tumorigenesis is a disease that is progressive in nature
Benign lesions show evidence for hyperplasia, dysplasia
and loss of differentiation, but are restricted in their
growth to the normal tissue environment.
Malignant lesions (cancer) display additional phenotypes
including the ability to invade into other tissue
environments, and to grow in tissues where the normal
cell never grows (metastasis).
The progressive disease is associated with multiple
changes in the cell including loss of function (tumor
suppressor genes) and gain of function (oncogenes)
changes. Oncology 401
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This document was uploaded on 02/14/2014.
- Fall '14