120910 Oncology 401 Lecture 3

Oncology 401 lecture 3 causes of human cancer chemical

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Unformatted text preview: cture 3 Causes of Human Cancer • • • Chemical Carcinogens Physical Carcinogens Biological Carcinogens Chemical Carcinogens Environmental and Lifestyle Factors in Cancer Table 2.7 Chemical Carcinogens that Cause Human Cancer Table 2.7 Examples of Chemical Carcinogens Figure 2.22 , Weinberg Activation of a Chemical Carcinogen: Aflotoxin B Figure 12.18b , Weinberg Ames Test: Mutagenicity of Chemical Carcinogens Figure 2.24, Weinberg Correlation Between Mutagenicity and Carcinogenicity of Chemicals Figure 2.25, Weinberg Physical Carcinogens • • • UV irradiation: Skin Cancer Radioactive Compounds: Leukemias, Lymphomas, Thyroid cancer X-rays: many types of cancers Mode of Action of UV Irradiation: Pyrimidine Dimers – Most Common Mutation: CC to TT Figure 12.14a , Weinberg...
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