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Unformatted text preview: understanding of how these proteins maintain
stress (Naim and Rosselli, 2009). It recently was reported that an
replication fork ﬁdelity in the context of ICL and synthesis
FA component stabilizes a specialized translesionother DNA
(TLS) DNA polymerase at nuclear foci upon DNA damage (Kim
et FANCD2).monoubiquitination involves an interaction with the
al., 2012 Thus, given the data and model presented here, it
replisome component proliferating cell nuclear antigen (PCNA
will be interesting to see if this polymerase stabilizing function
(Howlett et al., for other DNA polymerases and in particular noncould hold true 2009). Because BRCA2/RAD51 functionally interacts with FANCD2 (Long et al., 2011 Wang et al., 2004) and
specialized polymerases, because TLS; polymerases are unlikely
BRCA2/RAD51 alone is insufﬁcient for without eliciting DNA
to be involved when replication is stalledfork protection in the
absence of as by HU.
lesions suchFANCD2-Ub, a testable mechanistic model is tha
asOther FA a proteinm...
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- Fall '14