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slx4 binds to several colocalizes with pcna and

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Unformatted text preview: ay be found to FANCD2-Ub connects the part of proteins supercomplex act in this distinct pathway BRCA stabilization. FANCJ is important in processing DNA of forkand RAD51 proteins to replisome components to stabilize stalled forks and prevent G-rich regions (Hiom, 2010). In the secondary structures at fork collapse (Figure 6). This protection mechanismreplication afork stability, disruptionfor the observacontext of provides functional explanation of such G-rich tions that upon replication stalling both BRCA1 and BRCA2 structures may be crucial to create single-strand DNA stretches rapidly relocalize to replication foci containing PCNA (Chen long enough to support sufficiently stable RAD51 filaments et al., (SLX4) binds to several colocalizes with PCNA and FANCP1998). Moreover, FANCD2endonucleases implicated in RAD51 to foci (Cybulski and HU (Hussain ). al., 2004 and ICL processing in response to Howlett, 2011et However,) it is FANCD2 is found localized may have additional functions that feasible that FANCP (SL...
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