11.16.05 - Acetylcholine Structure o Acetyl group and choline group o Choline N and 3 CH3s How its function was detrmined o Loewi's xperiment o

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November 16, 2005 Acetylcholine Structure: o Acetyl group and choline group o Choline: N and 3 CH3s, How its function was detrmined: o Loewi’s xperiment o Placed two hearts in two beakers o Stimulated the vagus nerve of 1, connected it to the other, and both hearbeats slowed doen, one after the other. Due to Vagusstoff Evidenece that Ach is a Transmitter Ach is present in terminals Ach is released Enzymes for Ach synthesis are present in cleft. Acetocholine externally applied, it mimics the effect of a neurotransmitter. Ach-esterase – present in the cleft. Drugs block the neurotransmission (ex: curare). It also has the same effect on Ach. Drugs Inhibit esterase also inhibit neurotransmitter. (ex: eserine, nerve gas Interstin other NTs: dopamime, serotonin, norepherine, glycine, etc. Receptors for Neuro-Transmittors: Ligand-Gated Ion Channel o Example: Acetocholine o Two binding sites. o
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This note was uploaded on 02/11/2008 for the course BIO G 101 taught by Professor Gilbert,c. during the Fall '07 term at Cornell University (Engineering School).

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11.16.05 - Acetylcholine Structure o Acetyl group and choline group o Choline N and 3 CH3s How its function was detrmined o Loewi's xperiment o

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