Lecture-2014

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Unformatted text preview: replica/on. •  Muta/ons can cause changes in the amino acid sequence. GAA TGG CGA GAA ATA GGG à༎ GAA TGG CTA GAA ATA GGG Leu Ser Ala Leu Tyr Pro Leu Ser Asp Leu Tyr Pro •  Example of a Non synonymous muta/on, has changed the amino acid! •  Not all muta/on cause a change in the amino acid sequence. GAA TGG CTA GAA ATA GGG à༎ GAG TGG CTA GAA ATA GGG Leu Ser Asp Leu Tyr Pro Leu Ser Asp Leu Tyr Pro •  Example of a synonymous or silent muta/on. •  Nonsynonymous muta/ons produce a new protein. •  May do be^er in its func/on than the original sequence, or may do worse. Example: Sickle- cell anemia •  E.g muta/ons in β- hemoglobin cause impaired ability for the blood to transport oxygen. •  Muta/on in the 6th amino acid. •  Heterozygotes for this gene...
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This document was uploaded on 02/15/2014 for the course BIO 286 at Purdue University-West Lafayette.

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