PSYC 211- Midterm 1 Review

Es1mate regions of high and low metabolic ac1vity

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Unformatted text preview: : inhibits the effects of a neurotransmiaer on the post- synap1c cell -   Agonist: facilitates the effects of a neurotransmiaer on the post- synap1c cell Compe11ve vs Non- compe11ve -   Compe44ve binding: drug binds to the same site as the neurotransmiaer -   Noncompe44ve binding: drug binds to a different site from the neurotransmiaer Which of the following are true about NMDA receptors? 1)  2)  3)  4)  They are metabotropic receptors Glutamate binds to NMDA receptors Glutamate on its own can open the NMDA channel A magnesium ion must be removed from the NMDA ion channel to allow ca1ons to flow through the pore 5)  Ac1va1on of NMDA receptors increases the likelihood of an EPSP 6)  The NMDA ion channel is selec1ve for sodium ions Which of the following are true about NMDA receptors? 1)  2)  3)  -   -   -   4)  -   5)  6)  -   -   They are metabotropic receptors FALSE: they are ionotropic receptors Glutamate binds to NMDA receptors TRUE: NMDA are one of the 3 ionotropic glutamate receptors present (AMPA, kainate, NMDA) Glutamate on its own can open the NMDA channel FALSE: glutamate needs glycine or D- serine to bind to NMDA to open the channel A magnesium ion must be removed from the NMDA ion channel to allow ca1ons to flow through the pore TRUE: the ion pore is blocked by extracellular magnesium, making the receptor both voltage- dependent and ligand- gated Ac1va1on of NMDA receptors increases the likelihood of an EPSP TRUE: opening NMDA channels causes a influx of ca1ons, causing the intracellular voltage to become more posi1ve (depolarizing the cell) The NMDA ion channel is selec1ve for sodium ions FALSE: NMDA receptors are non- selec1ve for ca1ons (sodium, potassium, and calcium can pass through the ion channel NMDA receptors Ionotropic –  Nonselec1ve for ca1ons –  Calcium and sodium enters cell , potassium exits Is coac1vated by glut...
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