PSYC 211- Midterm 1 Review

Proper1es which have antagonis1c proper1es 1 2 3 4 5

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Unformatted text preview: index 1)  A drug that has a very large therapeu1c index will require a larger dose to achieve the desired therapeu1c effect 2)  The greater the therapeu1c index, the greater the dose required to produce toxic effect rela1ve to the dose required to produce the desired effect 3)  Drug A has a lower therapeu1c index than Drug B; therefore drug A will be toxic at a lower dose than drug B. 4)  It is one way to measure the margin of safety for a drug Which of the following statements are true regarding the therapeu1c index 1)  A drug that has a very large therapeu1c index will require a larger dose to achieve the desired therapeu1c effect –FALSE - The therapeu1c index is a measure of the margin of safety of a drug; to determine dose required for drug’s desired effect we need the dose- response curve 2)  The greater the therapeu1c index, the greater the dose required to produce toxic effect rela1ve to the dose required to produce the desired effect 3)  Drug A has a lower therapeu1c index than Drug B; therefore drug A will be toxic at a lower dose than drug B. –FALSE - The therapeu1c index is a ra1o, it only tells us the toxic does rela8ve to the effec1ve dose (the absolute value of each dose is not relevant) 4)  It is one way to measure the margin of safety for a drug Therapeu1c Index: We want a drug whose toxic dose is much higher than its effec4ve dose, i.e. high therapeu4c index Dose at which 50% of the animals show desired effect of the drug (ex. analgesia) Dose at which 50% of the animals show toxic effect of the drug (ex. death) Prozac is a serotonin reuptake inhibitor, which of the following is true about...
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