3.06.06 L60 - March 6 2006 Lecture 60 Differentiation II...

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March 6, 2006 Lecture 60: Differentiation II Frog Gastrulation: Revisited Ingression causes mesoderm to become somites &  lateral plates.  Notes that the anterior and posterior are not  perpendicular to dorsal  Notochord not made of cartilage PATTERN FORMATION: MORPHAGENS &  APOSTOSIS Morphagens – regulatory proteins during transcription A cascade of transcription factor expression Drosophila fate map & Body segments. 5 Sets of Genes Egg Polarity (4) Gap Genes (6) Pair-Rule genes (8)  Segment Polarity Genes (10) Homeotic Selector Genes Egg-Polarity, Gap, Pair-Rule, and  Segment Polarity genes are a cascade,  meaning one sets off the next, etc. Order is important because it divides up  the body in a sequential cascade. Egg Polarity Genes 4 genes (n=4) Produced by follicle cells 4 distinct intracellular gradients that determine o Posterior v. anterior
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