4 kcalmol glutamate glutamine net g 39 kcalmol atp

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Unformatted text preview: = -7.3 kcal/mol Endergonic ∆G= +3.4 kcal/mol Glutamate Glutamine Net: ∆G= -3.9 kcal/mol ATP coupled reac0ons P removed from ATP Releasing energy substrate gets “activated” P attached P removed from activated substrate (releasing energy) to complete the reaction ATP/ADP Cycle Used for endergonic reactions in cells From exergonic, catabolic breakdown of food Ac0va0on Energy Figure 4- 8a p78 Enzymes An Example: Adenosine Deamina0on unstable Substrate Higher energy state Transition State Product Enzyme-Substrate Interaction Active site Enzyme & reactant Enzyme-substrate complex Enzyme & product Enzyme & Substrate Concentra0ons Increasing enzyme Lots of substrate Increasing substrate Constant enzyme cxn Figure 4- 12a p81 Competitive Inhibition Inhibitor Active site Enzyme Substrate Noncompe00ve/Allosteric Regula0on ligand Active form ligand Inactive form Allosteric Ac0va0on Allosteric ac6vator Allosteric Ac6ve site site Substrate 1 Enzyme in low- affinity state 2 High- affinity state 3 High- affinity state Figure 4- 14 p83 Feedback Inhibi0on Allosteric Interaction pH regulation Temperature Regula0on Figure 4- 17 p84 RNA World...
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This note was uploaded on 02/17/2014 for the course CHEM 153C 153C taught by Professor Clarke during the Winter '14 term at UCLA.

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