lecture11+mendel+2

25 025 025 025 total linkage 050 050 0 0

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Unformatted text preview: homology with humans Why wasn’t assortment en2rely independent? Thomas Hunt Morgan 1866- 1945 Genotypes Bb Vgvg bb vgvg Bb vgvg bb Vgvg Independent 0.25 0.25 0.25 0.25 Total linkage 0.50 0.50 0 0 Observed 0.41 0.09 0.08 0.42 0.17 frequency Meio2c crossover and recombina2on We can use recombina2on rates to create linkage maps of gene order Map units = Cen2morgans (cM) = 100 x recombina2on frequency An example 0.1 0.2 A B C a b c Possible gametes: AxB? AxC? Freq? ABC abc Abc aBC ABc abC AbC aBc P of no crossover? P of AB crossover? P of BC crossover? P of double crossover? Sex- linked genes Hemophilia Red- green color blindness Black/orange cat coat color Queen Victoria: hemophilia carrier Pleiotropy: allelic varia2on at one locus affects mul2ple traits Pigmenta2on and hearing: 40% of blue- e...
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