Topic 2 - lipid bilayer (lec 3)

There are no colvalent bonds holding this strucutre

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Unformatted text preview: olvalent bonds holding this strucutre together. It is all held together by non-colvalent interactions. > That lipid bilayer forms the structural basis of the membrane and is also the basis of the permeablity barrier. Than studded into that lipid bilayer is the unique complement of proteins of the perticular membrane, and those proteins in many cases are responsible for specific fuctions of the membrane. > The whole thing is 10 nanometers thick, that is alot to pack into a very small structure > The fluid membrane, there can be a # of experiments to show the fluid nature of the membrane. Membrane structure Fluid mosaic model Lipid-protein assembly in which components are held together in a thin sheet by non-covalent bonds Two fluid lipid layers – structural backbone, permeability barrier Mosaic of proteins – unique complement responsible for specific functions ~10 nm thick BIO 1140 – SLIDE 5 Fig. 5.1 Membrane structure Fluid mosaic model Lipid-protein assembly in which components are held together in a thin sheet by non-covalent bonds Two fluid lipid layers – structural backbone, permeability barrier Mosaic of proteins – unique complement responsible for specific functions ~10 nm thick BIO 1140 – SLIDE 6 > Membranes can be talored interms of their structure to the function they are carring out, so in one sense all membranes are the same. Membrane can be different aswell, as the structure of the membrane is talored to a specific function. For example were going to look at mitochondria, we can see that the inner membrane of the mitrochondria it is very enriched in protein. 76% protein and 24% lipid. On the other extream the schwan cells that form an insulating layer around the neurons are highly enriched in lipids 82% lipids and only 18% proteins. Fig. 5.2 > The first experiment, what they did was that they took two lines of cells, one was a human cell line, and the other was a mouse cell line. > They labled proteins in those cell lines, the membrane proteins with different coloured lables. In thi...
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This note was uploaded on 02/19/2014 for the course BIO 1140 taught by Professor Fenwick during the Winter '07 term at University of Ottawa.

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