I n h i b i t i o n by g e m i n i n g e m i n i n i

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Unformatted text preview: anaphase. I n h i b i t i o n by g e m i n i n . G e m i n i n i s a s m a l l p r o t e i n t h a t b i n d s a n d i n h i b i t s C d t 1 ( M c G a rr y & K i rs c h n e r, 1 9 9 8 ; W o h l s c h l e g e l et al , 2 0 0 0 ; Ta d a et al , 2 0 0 1 ) . S o f a r, i t h a s b e e n d e s c r i b e d o n l y i n m e t a z o a ns. G e m i n i n is u b i q u i t y l a t e d by t h e A P C / C d uri ng l a t e m i t o s i s a n d e a r l y G 1 . I n s o m a t i c c e l l s , t h i s a c t i o n t a rg e t s i t f o r p r o t e o l y s i s ; h o w e v e r, i n e a r l y e m b r y o s , u b i q u i t y l a t i o n o f g e m i n i n l e a d s t o i t s i n a c t i v a t i o n r a t h e r t h a n i t s d e gr a d a t i o n ( H o d gs o n et al , 2 0 0 2 ) . L e v e l s o f a c t i v e g e m i n i n a r e h i g h d u r i n g S , G 2 a n d m i t osis, a n d t h is is i m p ort a n t i n pre v e n t i ng re-l i c e nsi ng o f re p l ic a t e d D N A ( Q u i n n et al , 2 0 0 1 ; M i h a y l o v et al , 2 0 0 2 ; M e l i x e t i a n et al , 2 0 0 4 ; Z h u et al , 2 0 0 4 ; L i & B l...
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This document was uploaded on 02/21/2014 for the course BIOCHEMIST 312 at UC Davis.

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