In m e t a z o a ns d o w nregu l a t i o n o f c d t

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Unformatted text preview: g u y e n et al , 2 0 0 1). In m e t a z o a ns, d o w nregu l a t i o n o f C d t 1 a l o n e se e ms t o b e t h e m o st i m p o rt a n t m e c h a n i s m t h a t p r e v e n ts r e - l i c e n s i n g o f r e p l i c a t e d D N A , a s o v e r e x p r e ss i o n o f C d t 1 o r e l i m i n a t i o n o f g e m i n i n c a n c a u s e e x t e n s iJ.e r e -rand iT.a t i o n ( Q u i n n Rep. l , :1028; M i h a y l o v v Blow e p l c Tanaka, EMBO et a 6 2 0 0 1 27 et al , 2 0 0 2 ; V a z i r i et al , 2 0 0 3 ; Z h o n g et al , 2 0 0 3 ; M e l i x e t i a n et al , 2 0 0 4 ; Z h u et al , 2 0 0 4 ; L i & B l o w , 2 0 0 5 ) . I t i s c u r i o u s t h a t m e t a z o a n s , i n w h i c h t h e c o n s e q u e n c e s o f g e n e t i c i n st a b i l i t y a r e gr e a t e r ( a s i t m i g h t c a u s e c a n c e r) , d o n o t r e l y o n t h e n u m e r o u s m e c h a n i s m s t h a t a r e u s e d b y b u d d i n g y e a s t . O n e p o ss i b l e e x p l a - At G1/S, MCM loading proteins are is ubiquitinated and destroyed by the proteasome At anaphase, cohesin is ubiquitinated and destroyed by the proteasome C d c 6 , C d t 1 a n d M c m 2–7 are c o m p c o m p l e x ( p r e -R C ) o f p r o t e...
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This document was uploaded on 02/21/2014 for the course BIOCHEMIST 312 at UC Davis.

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