Th e c o h e s i n c o m p l e x i s l o a d e n d o

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Unformatted text preview: c 1 a Cohesin Further licensing prevented t u r e . Th e c o h e s i n c o m p l e x i s l o a d e n d o f M p h a s e i n f i ss i o n y e a s t a n d m i n b u d d i n g y e a s t . Th i s l o a d i n g p r o c e Fig 1 | Overview of the licensing and cohesion cycles. A small segment of i ng o f Sc c 2 (a lso c a l l e d M is4 a n d N i chromosomal DNA, encompassing three replication origins, is shown during 2 0 0 0 ; To m o n a g a et al , 2 0 0 0 ) . C o h e G1, S and G2. Mcm2–7 and cohesin are loaded during G1. During S phase, the AT Pa s e a c t i v i t y o f S m c 1 a n d S m Mcm2–7 complex is displaced from DNA as it replicates, and cohesion is W e i t z e r et al , 2 0 0 3 ) . S i m i l a r t o l i c established. During anaphase, cohesin is cleaved, thereby allowing segregation m igh t i n vo l v e o p e n i ng u p t h e c o h e of sister chromatids. a r o u n d t h e D N A . I n Xenopus e gg e x 28 t o chro m oso m es d e p e n ds o n t h e chro m a t i n , w h i ch t h ere f ore t igh t l y o n t o D N A . D uri ng S p h ase , t h e c o h esi n c o m p l e x est a b l ish es a ( G i l l e s p i e & H i ra n o , 2 0 0 4 ; Ta k a h a s p hysi c a l l i n k (c o h esi o n) b e t w e e n sist er c hro m a t i ds. C o h esi n is b u d d i n g y e a st , c o h e s i n l o a d i n g t a re q u ire d f or m a i n t e n a n c e o f t h is c o h esi o n , a n d f or e nsuri ng t h a t p r e -R C p r o t e i n s a n d , i n c o n t r a s t t o DNA condenses Cell divides M h p://en.wikipedia.org/wiki/Cell_cycle The end of the end: a problem for linear chromosomes The end of the end: a solution 29 Telomeres!!! Telomerase is a ribonucleoprotein 30...
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This document was uploaded on 02/21/2014 for the course BIOCHEMIST 312 at UC Davis.

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