Th e l i c dna decondensese nsi ng re a c t i o n h

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Unformatted text preview: i n s t h a t a r d uri ng G 1 . Th e l i c DNA decondensese nsi ng re a c t i o n h as b e e n m a t i n o f Xenopus s p e r m a t o z o a u s i n Decisiondto divide, i n a d d i t i o n t o a c h a n M c m 2–7 t h a t is re q u ire d f or t h e i n i t i a l b i n d i n Metaphase Anaphase et al , 2 0 0 1 ) . O R C b i n d s t o t h e D N A M C dt1. RC , ee LicensingO7 o n tC dD 6 a n d u tdatr1e anro t resqsu of o c N A , b C M c m 2– M origins:oloading 7 . Th is is c o nsist e n t w i ng f M c m 2– M ng as c l a m h pe G2 G1 withicMCMiatandi npalro a d edr tth ea tDoN A n(s iu l oses aga oun Fg S MM cohesin t o l o a d se v era l M c m 2–7 h e x able re p l i c a t i o n origi n ( O R C -b i n d i ng M M c m 2– h e M MCM loading70 0 5)x. a m ers asso c i a t e d w i t h D utta , 2 proteins Th e c o h esi n c o m p l e x c o nsists o M Sc c 1 ( o l d d M destroyed Aa1ls2 ; cNaalsem yM c& 1H a nrdi nRa d 2 1 M and S / th a e g, 2 0 0 a n i n tra m o l e c u l a r a n t i p a ra l l e l c o i DNA Synthesis g l o b u l a r a m i n o ( N )- a n d c a r b o x y ( ( A n d e rs o n et al , 2 0 0 2 ; H a e r i n g et M Mcm2-7 Licensing and cohesin loading d i m e r i z e t h r o u g h t h e i r c e n tra l d o m e r o d i m e r, w h i c h i s c l o s e d b y S c...
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This document was uploaded on 02/21/2014 for the course BIOCHEMIST 312 at UC Davis.

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