1385953320_755__Lecture%252B31_HIV%252Blatency%252Band%252Bcure (1)

1385953320_755__Lecture%252B31_HIV%252Blatency%252Band%252Bcure (1)

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Lecture’31:’Dec’2 HIV’latency’and’eradica6on
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Integra6on’is’an’essen6al’step’in’ the’HIV’life’cycle’ Once integrated, HIV resembles cellular genes…
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Expression’from’the’HIV’LTR’ promoter’requires’viral’Tat’protein’
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Like’cellular’genes,’HIV’expression’is’ afected’by’epigene6c’Factors’ • Cellular chromosomes (chroma;n) can be held in an “open” or “closed” conforma;on by histones - this is regulated, in part, by histone modiFca;ons, including acetyla;on of lysine residues - Histone acetyl transferase enzymes (HATs) add acetyl groups and promote the “open” (ac;ve) form - Histone deacetylase enzymes (HDACs) remove acetyl groups and promote a “closed” (inac;ve) chroma;n structure
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HIV’establishes’a’“latent”’infec6on’ mainly’in’res6ng’CD4+’T’cells’ •’A’reservoir’of’latent’HIV-infected’cells’is’ ’ established’very’early’following’infec6on’ ’ (Frst’days’to’weeks)’and’is’maintained’for’ ’ the’life’of’the’host,’even’in’the’presence’of’ ’ an6retroviral’drugs’
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Is an HIV “cure” possible?
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1385953320_755__Lecture%252B31_HIV%252Blatency%252Band%252Bcure (1)

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