1385953320_755__Lecture%252B31_HIV%252Blatency%252Band%252Bcure (1)

Pam3csk4 induces viral reacvaon the absence of t cell

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Unformatted text preview: e 3. Signalling triggered by PAM3CSK4. NF- kB NFAT AP- 1 MAPK Figure 4. PAM3CSK4 triggers Calcium- flux. • Result is consistent with ac6va6on of NFAT • Note that Pam3CSK4, Pam2CSK4, and LAM- MS are TLR2 agonists, but react with different TLR2 heterodimers Pam3CSK4 (TLR1/2): Pam2CSK4 (TLR2/6): Figure 5. PAM3CSK4 induces viral reac;va;on in a Tat- dependent manner • Flavopiridol prevents Tat- mediated HIV transcrip6on by blocking the ac6vity of pTEFb pTEFb (posi6ve transcrip6on elonga6on factor) is a protein kinase composed of cyclin- dependent kinase (CDK) 9 and cyclin T Figure 6. PAM3CSK4 induces viral reac;va;on the absence of T cell ac;va;on or prolifera;on • Note: ac6va6on of T cells using CD3+CD28 an6body is not clinically viable, since overs6mula6on of the immune system would result in...
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