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2.06.06 L48 - Lecture 6 DNA and Replication Watson Crick...

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May 13, 2009 Lecture 6: DNA and Replication Watson & Crick Model Two strand running in opposite directions Produces spiral helix. Structure of DNA Composed of Deoxyribose sugar, phopate groups, 2 phosphate linkages,  5’, 3’, antiparallel Double helix Dna makes itself, and RNA, which then produces proteins.  What is the Mechanism of Replication? Watson and Crick propose a “template” model for each strand Kornberg: Learned that DNA Polymerase was necessary for test tube replication Semi-consrvation o Semi-conservation: DNA is half conserved, half new o Conservative: Entire DNA is new, parent helix is retained, and entire new daughter helix  is produced. Meselson & Stahl – Confirmed visually (using staining) that the semi-conservative model  is correct. DNA Replication: Prokaryotes Single point of origin Replication bubble is formed as are two replication forms 2 strand of dna unzip and a new strand is laid down on each string.
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