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Unformatted text preview: May 13, 2009 Lecture 6: DNA and Replication Watson & Crick Model Two strand running in opposite directions Produces spiral helix. Structure of DNA Composed of Deoxyribose sugar, phopate groups, 2 phosphate linkages, 5, 3, antiparallel Double helix Dna makes itself, and RNA, which then produces proteins. What is the Mechanism of Replication? Watson and Crick propose a template model for each strand Kornberg: Learned that DNA Polymerase was necessary for test tube replication Semi-consrvation o Semi-conservation: DNA is half conserved, half new o Conservative: Entire DNA is new, parent helix is retained, and entire new daughter helix is produced. Meselson & Stahl Confirmed visually (using staining) that the semi-conservative model is correct. DNA Replication: Prokaryotes Single point of origin Replication bubble is formed as are two replication forms 2 strand of dna unzip and a new strand is laid down on each string.2 strand of dna unzip and a new strand is laid down on each string....
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This note was uploaded on 02/11/2008 for the course BIO G 101 taught by Professor Gilbert,c. during the Fall '07 term at Cornell University (Engineering School).
- Fall '07