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Unformatted text preview: e and activated
Guanalyl cyclase and catalyzes GDP to cGMP, cGMP
binds to cGMP channel, causes electrical impulse, and
worm knows that it smelt the benzaldehyde Activation of a GPCR can
lead to changes in
transcription, ion channel
activity, altered metabolism,
another molecule activated by pKG affects
transcription and stops other cycle so that you
do not know that you are smalling
benzaldehyde. transcription and translation
takes time. you small the popcorn and then get
used to small, get used to it over time Crosstalk: signaling pathways can interact For example, cellular
decisions to live or die
depend upon integration of
multiple signals that directly
interact with one another Yamaguchi H, Chang SS, Hsu JL, Hung MC.
(2013). Signaling cross-talk in the resistance
to HER family receptor targeted therapy.
Oncogene. doi: 10.1038/onc.2013.74. Crosstalk: signaling pathways can interact
hormones Growth factors Seven pass transmembrane receptors G protein Phospholipase C G protein Adenylate cyclase IP3 Diacylglycerol A kinase Ras- activating protein
Cyclic AMP Adapter protein Protein kinase I calmodulin
CaM kinase Gene regulatory proteins Protein kinase II
C kinase Protein kinase III Gene target proteins Signaling outcome depends on context
just because signaling pathway works a
certain way in one cell, doesnt mean it
will work the same way in other cell. acetylcholine Heart muscle:
decreased contraction Sa...
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.
- Winter '08
- Cell Signaling