Lecture 3--cell signaling

How do different lipids end up in different membranes

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Unformatted text preview: phosphatidylinositol (PI) in the lipid bilayer. Enzyme-linked receptors Extracellular signal molecule Intracellular signaling pathway FAST (<sec to mins) Altered protein function Cell surface receptor DNA RNA Altered gene expression Altered cytoplasmic machinery Altered cell behavior SLOW (mins to hours) Activation of a Receptor Tyrosine Kinase often growth factors, FGF, VAGF, insulin that have this rceptors. wproblem with premature birthsa, is that their lungs and circulatry systems arent Signal molecule in form of a dimer developed wellso they cant get enough oxygen and cau brain cells to die; type of cells that die are the ones that promote the growth and prolyferation of oligodendrocytes. in mice, if they add FGF, this reduced the birth defect that would have happened from premature birth. do not want ot add to babies because growth factors promote cancer so need to be careful medically importat homodimers when active; theyre in active, they are not dimerized, when signaling mol comes a...
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