This preview shows page 1. Sign up to view the full content.
Unformatted text preview: phosphatidylinositol (PI) in the lipid bilayer. Enzyme-linked receptors
Extracellular signal molecule Intracellular signaling
(<sec to mins) Altered
function Cell surface
RNA Altered gene expression Altered cytoplasmic machinery Altered cell behavior SLOW
(mins to hours) Activation of a Receptor Tyrosine Kinase
often growth factors, FGF, VAGF, insulin that have this rceptors.
wproblem with premature birthsa, is that their lungs and circulatry systems arent
in form of a dimer developed wellso they cant get enough oxygen and cau brain cells to die; type of cells
that die are the ones that promote the growth and prolyferation of oligodendrocytes. in mice, if they add FGF, this reduced the birth defect that would have happened from premature birth. do not
want ot add to babies because growth factors promote cancer so need to be careful medically importat
homodimers when active; theyre in active, they are not dimerized, when signaling mol comes a...
View Full Document
- Winter '08
- Cell Signaling