Lecture 3--cell signaling

Nuclear hormone receptor translocation monitored with

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Unformatted text preview: e with hormone Androgen Receptor Retinoic Acid Receptor The first step in signal transduction: ligand activates receptor Ligands can be soluble or membrane-bound Receptors can be on the cell surface or intracellular signal receptor Cell Surface Receptors Ion channel linked receptor ions 1. Ion channels - activation leads to a flow of ions that causes an electrical effect G protein linked receptor G protein enzyme Activated G protein Activated enzyme Enzyme linked receptors Signal molecule in form of a dimer Active catalytic domain Inactive catalytic domain 2. G - protein linked receptors - binding to ligand promotes the release of an activated form of a membrane bound protein that then diffuses in the plane of the plasma membrane. 3. Enzyme linked receptors activation upon ligand binding induces an ezymatic activity at the cytoplasmic end of the receptor that leads to another series of cytoplasmic signals G-protein Coupled Receptors olfatory receptors: sence light: opsins; rhodopsin has an inorganic molecule inside called retinol and when photon of light hitsretinal, it changes conformation and fucnction snake membrane seven times the most abundant family of receptors in genome, not a familty a super family because contin sub families f proteins that has=ve sequence similarities, called g protein coupled receptors becausethey are likned down steam to gproteins. seven transmembrane receptors also, surpentine receptors (other name) snake in and out of membrane...
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.

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