{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Lecture 3--cell signaling

Possibilities 1 scaffolds bring two signal

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: folds prevent promiscuous interactions between components of different pathways Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Park SH, Zarrinpar A, Lim WA. Science. 2003 Feb 14;299(5609):1061-4. Signal transduction summary 1. Cells receive many different kind of signals that they transduce to cellular responses 2. Techniques for studying signal transduction include genetics, RNAi, Co-IPs, localization methods, phosphospecific antibodies, and transcriptional read-outs 3. Nuclear hormone receptors act intracellularly 4. G-protein signaling makes use of cAMP and lipids as second messengers 5. Tyrosine kinase receptor initiate signaling by dimerization and phosphorylation 6. Phosphorylation is a common motif in signal transduction pathways: Map kinase signaling...
View Full Document

{[ snackBarMessage ]}