Lecture 3--cell signaling

Possibilities 1 scaffolds bring two signal

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Unformatted text preview: folds prevent promiscuous interactions between components of different pathways Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Park SH, Zarrinpar A, Lim WA. Science. 2003 Feb 14;299(5609):1061-4. Signal transduction summary 1. Cells receive many different kind of signals that they transduce to cellular responses 2. Techniques for studying signal transduction include genetics, RNAi, Co-IPs, localization methods, phosphospecific antibodies, and transcriptional read-outs 3. Nuclear hormone receptors act intracellularly 4. G-protein signaling makes use of cAMP and lipids as second messengers 5. Tyrosine kinase receptor initiate signaling by dimerization and phosphorylation 6. Phosphorylation is a common motif in signal transduction pathways: Map kinase signaling...
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.

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