Unformatted text preview: surface receptors transduce signals into cells through a
series of cytoplasmic biochemical interactions Signaling pathways consist of a series of proteins.
– Each protein in a pathway alters the conformation of the next protein.
– Protein conformation is often altered by phosphorylation.
– Target proteins ultimately receive a message to alter cell activity series of biochemical reactions that allow a cell to receive signals from
the outside and transporm it into cellular out come
1. receptor interacts with signal from outside, that boud form changes
its confomation and enzymatic activity, which allows it to change a
protein fdown stream, which can then trnasform information that goes
down cascade of events to rsult in cellular respose (change in
transcipriton, change in cytoskeleton, migrate, controls cells life/death Signal transduction pathways are often
portrayed as a linear set of reactions
siplistic view, Prabakaran lab Pathways are not always linear: pathways can
converge, diverge or cross talk one cprotein can activate
many other proteins, and they
can even interact with different
pathways; cell has to be
compouter to integrate
outcome Prabakaran lab Convergence: multiple signals can activate the
promotes cell survival,
survival protein BAD
by interacting with other
proteins called PCL or
cell killers; inhibts cell
killers; lots of signal
required to keep cell
alive. this is one o...
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- Winter '08
- Cell Signaling