Lecture 3--cell signaling

Signal cells surface receptors transduce signals into

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Unformatted text preview: surface receptors transduce signals into cells through a series of cytoplasmic biochemical interactions Signaling pathways consist of a series of proteins. – Each protein in a pathway alters the conformation of the next protein. – Protein conformation is often altered by phosphorylation. – Target proteins ultimately receive a message to alter cell activity series of biochemical reactions that allow a cell to receive signals from the outside and transporm it into cellular out come 1. receptor interacts with signal from outside, that boud form changes its confomation and enzymatic activity, which allows it to change a protein fdown stream, which can then trnasform information that goes down cascade of events to rsult in cellular respose (change in transcipriton, change in cytoskeleton, migrate, controls cells life/death Signal transduction pathways are often portrayed as a linear set of reactions siplistic view, Prabakaran lab Pathways are not always linear: pathways can converge, diverge or cross talk one cprotein can activate many other proteins, and they can even interact with different pathways; cell has to be compouter to integrate outcome Prabakaran lab Convergence: multiple signals can activate the promotes cell survival, survival protein BAD by interacting with other proteins called PCL or cell killers; inhibts cell killers; lots of signal required to keep cell alive. this is one o...
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.

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