Unformatted text preview: livary gland: secretion Skeletal muscle:
increased contraction Acetylcholine can induce different responses depending on the
cell type and or receptor Signaling networks can be very complex slides here on drop
box Example: innate immune signaling through Toll-like receptors
Oda K, Kitano H. (2006). A comprehensive map of the toll-like receptor signaling network.Mol Syst Biol.
2006;2:2006.0015. Prabakaran lab How is signaling specificity and efficiency maintained
in a crowded cytoplasm with so much opportunity for
cross-talk, divergence and convergence? “Scaffold” proteins have been proposed to play a role in
maintaining signaling specificity and efficiency Scaffold Scaffold Response to mating pheromone
in yeast Response to cardiac
hypertrophy in mammals Pawson and Scott (2010). Signal integration through blending, bolstering and bifurcating of intracellular information.
Nature Structural & Molecular Biology 17, 653–658. Experimental questions in signal
--What proteins participate in a signal transduction pathway?
--Do two proteins physically interact in the presence/ab...
View Full Document
- Winter '08
- Cell Signaling