Lecture 3--cell signaling

Acetylcholine heart muscle decreased contraction

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: livary gland: secretion Skeletal muscle: increased contraction Acetylcholine can induce different responses depending on the cell type and or receptor Signaling networks can be very complex slides here on drop box Example: innate immune signaling through Toll-like receptors Oda K, Kitano H. (2006). A comprehensive map of the toll-like receptor signaling network.Mol Syst Biol. 2006;2:2006.0015. Prabakaran lab How is signaling specificity and efficiency maintained in a crowded cytoplasm with so much opportunity for cross-talk, divergence and convergence? “Scaffold” proteins have been proposed to play a role in maintaining signaling specificity and efficiency Scaffold Scaffold Response to mating pheromone in yeast Response to cardiac hypertrophy in mammals Pawson and Scott (2010). Signal integration through blending, bolstering and bifurcating of intracellular information. Nature Structural & Molecular Biology 17, 653–658. Experimental questions in signal transduction --What proteins participate in a signal transduction pathway? --Do two proteins physically interact in the presence/ab...
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online