Lecture 3--cell signaling

Beta and potassium channel activation interact with

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: brane Extracellular space cytosol rate limiting step is the GTP binding step to alpha, alpha hydrolyzed GTp to GDP and k channels close and inatcivates g protein Inactive G protein Closed K+ channel Activated ! subunit Channel opening Open K+ channel opens, causes potassium to leak out cell, hyperpolarizes cell. gets different Binding ofin heart and muscle. in response the neurotransmitter directly open muscle: the acetylcholine k c to its acetylcholinehannel G-protein- linked receptor on heart muscle Activated "# complex binds to and opens a K+ channel in the heart plasma membrane inactivation Closed K+ channel Inactivation of the a subunit by hydrolysis of bound GTP causes reassociation with the "# complex. Enzymes activated by G protein catalyze the synthesis of intracellular messenger molecules Activated enzyme Activated "# complex Activated ! subunit of G protein second messangers re not the second protein in the pathway, they can be generated anywhere in pathway, small molecules that get amplified...
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online