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Lecture 3--cell signaling

Kinase pathway controls mating in yeast nuclear

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Unformatted text preview: . (1999). Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity. Mol Biol Cell 10(5):1553-68. In yeast, MAP kinase pathways are required for responses to mating pheromone and high osmoloraity Ste5 and Pbs2 are scaffolding proteins that bind to all of the MAP kinase components. What is their role in transduction? Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Park SH, Zarrinpar A, Lim WA. Science. 2003 Feb 14;299(5609):1061-4. Specific signals are transduced into specific cellular outcomes by a series of biochemical interactions How is signal specificity and efficiency maintained in a crowded cytoplasm? What is the role of scaffolds in signal transduction? Possibilities: 1. Scaffolds bring two signal transduction components into proximity so that they can interact 2. Scaffolds hold signal transduction components in precise stereochemical orientations so that interacting interfaces come into contact 3. Scaf...
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