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Unformatted text preview: DP for GTP Crystal structure of an activated beta-adrenergic
receptor with G-protein G-protein either apha or beta gamma can interact with other
! subunit Target
protein molecules down stream.
activated alpha unit can interact with target protein.
Extracellular spaceand can interact with adenylyl cyclase and activates
activity, make cyclic amp and
Activation of target protein
by ! subunit of G protein inactivation Re-formed
inactive G protein Inactive target protein 1. Activated ! subunit
encounters and binds its target
protein and activates it.
2. The GTP on the ! subunits
hydrolyzed to GDP by the !
subunit’s intrinsic GTP’ase
activity. 3. Inactivation leads to binding
to the " and # subunits when
The acetylcholine receptor GOCRactivation of alpha, beta and
inet the GOC r is activated you
an example of G-proteingamma. beta and potassium channel
activation interact with
the channel acetylcholine alpha subunit is the one
that interacts with the Activated "#
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.
- Winter '08
- Cell Signaling