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Unformatted text preview: , point: annsee that cAMP is spreading from where source was activated, spreading
A nerve cell in cultureand activating other parts ofserotonin shows significant
in the presence of cell increase in cAMP levels as soon as 20 seconds Signaling activated by phospholipase now effector ptoein is a phospholipase; phospholipase
phospholipids, cleaves pep3 thatha ring phosphorylated 3
time. releases enasytol part and the part left over , lipid par,
now missing phoshpho lipid head part now called DAG Some G protein
G protein linked
activate G proteins
diacylglycerol that can activate
phopholipase C. Activated G protein
! subunit Protein
reticulum Open Ca+2
channel This enzyme gives
rise to IP3 and
IP3 leads to Ca+2
increases in the
cytosol. How do different lipids end up in different
membranes? Lipids can be cleaved by lipases Lipid second messengers Generation of second messengers as a result of ligand-induced breakdown of...
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.
- Winter '08
- Cell Signaling