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Lecture 3--cell signaling

Molecules tht fluoresce when bound to camp heat map

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Unformatted text preview: , point: annsee that cAMP is spreading from where source was activated, spreading A nerve cell in cultureand activating other parts ofserotonin shows significant in the presence of cell increase in cAMP levels as soon as 20 seconds Signaling activated by phospholipase now effector ptoein is a phospholipase; phospholipase phospholipids, cleaves pep3 thatha ring phosphorylated 3 time. releases enasytol part and the part left over , lipid par, Signaling molecule now missing phoshpho lipid head part now called DAG Some G protein Inositol phospholipid receptors can Activated G protein linked phospholipase C receptor activate G proteins diacylglycerol that can activate phopholipase C. Activated G protein ! subunit Protein kinase C Inositol 1,4,5 triphosphate (IP3) Endoplasmic reticulum Open Ca+2 channel This enzyme gives rise to IP3 and diacylglycerol from inositol phospholipid IP3 leads to Ca+2 increases in the cytosol. How do different lipids end up in different membranes? Lipids can be cleaved by lipases Lipid second messengers Generation of second messengers as a result of ligand-induced breakdown of...
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