Lecture 3--cell signaling

Subunit of g protein second messangers re not the

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Unformatted text preview: in pathway. most common messengers are cAMP, cGMP, calcium, lipids (IP3), DAG Many intracellular messenger molecules diffuse widely to act on target proteins in various parts of the cell cAMP signals gene transcription Signal molecule Activate adenylate cyclase receptor Activated a subunit of G protein cytosol nucleus Cyclic AMP Inactive A-kinase Activated A-kinase cAMP activates A-kinase in the cytosol, which then moves into the nucleus and phophorylates a gene regulatory protein. Once phophorylated, the gene regulatory protein is able to stimulate the transcription of target genes Nuclear pore Activated phophorylated gene regulatory protein Activated A-kinase Activated target gene DNA RNA transcription translation New protein The cAMP pathway can activate enzymes and turn on genes 0 seconds 20 seconds serotonin Activation of G protein linked receptors can alter the concentration fluorescent reporter, of intercellular cAMP. molecules tht fluoresce when bound to cAMP heat map of responce; bluse lowest amount of cAMP, red most amount of cAMO; get rapid responce; can be calized, not alll over the cell...
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