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Lecture 3--cell signaling

This is one of main nodes for that each pathways

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Unformatted text preview: f main nodes for that. each pathways leads to phosphorylation of bad in distinct positions. all affect ability of bad to inhibit PCL. each phosphorylation promote bBAD binding and cause death, but different combinations can lead to strength of signaling Lizcano JM, Morrice N, Cohen P. (2000). Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem J. 2000 Jul 15;349(Pt 2):547-57. Convergence: multiple signals can activate Ras Extracellular matrix G protein coupled integrin GRB2 Sos complex leads to ctivation of important kinse RAS leads to activation of MAP kinase cascade Growth factors Neurotransmitter hormones Receptor tyrosine kinase receptor Sos Grb2 Sos Sos Grb2 Ras MAP kinase Cascade Grb2 Divergence: one signal can elicit multiple outcomes activating G protein. can activate ion channel, or send signals into nucleus, alter metabolism of cell. GOCR 7 transmembrane receptors: sends olfactory molecules. GPCR in wors for benzaldehyd...
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