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nodes for that. each
pathways leads to
phosphorylation of bad
in distinct positions. all
affect ability of bad to
inhibit PCL. each
promote bBAD binding
and cause death, but
can lead to strength of
signaling Lizcano JM, Morrice N, Cohen P. (2000). Regulation of BAD by cAMP-dependent protein kinase is
mediated via phosphorylation of a novel site, Ser155. Biochem J. 2000 Jul 15;349(Pt 2):547-57. Convergence: multiple signals can activate Ras
Extracellular matrix G protein
coupled integrin GRB2 Sos complex
leads to ctivation of
important kinse RAS
leads to activation of
MAP kinase cascade Growth factors
hormones Receptor tyrosine
kinase receptor Sos
Grb2 Sos Sos
Grb2 Ras MAP kinase Cascade Grb2 Divergence: one signal can elicit multiple
activating G protein. can activate ion channel, or send
signals into nucleus, alter metabolism of cell. GOCR 7
transmembrane receptors: sends olfactory molecules.
GPCR in wors for benzaldehyd...
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.
- Winter '08
- Cell Signaling