Lecture 6--the cytoskeleton-1

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Unformatted text preview: rtant for migration; uses focal adhesion contacts with substrates; Actin is in every cell and has diverse functions Structure of actin filaments like double helix; all subunits are same proteins(blue and purple) is like two protofilaments twisted around eachother; Direct visualization of secondary structures of F-actin by electron cryomicroscopy. Fujii T, Iwane AH, Yanagida T, Namba K. Nature. 2010 Oct 7;467(7316):724-8. Skeletal Muscle Muscle bundle Muscle “cell” fiber muscle fibers are muticnucleate cells; nucleai pushed off to the sidel largest part of these muslce fibers are filled up with structure callesd sacrcoemre(actin based structure) actin filaments (thin filaments) myosin (motors) sctin gets organized in clear way as stripes, and myosins have head tha attaches to the actin; myosin moves actin Cytoskeleton summary 1. Functions of the cytoskeleton: structure, attachment, compartmentalization, motility, transport, cell division 2. Methods for studying the cytoskeleton: EM, antibodies, fusion proteins, drugs, in vitro assays 3. Microtubules consist of alpha and beta tubulin dimers assembled into protofilaments, which in turn form large hollow filaments 4. Microtubule assembly/stability is regulated by GTP/GDP binding 5. MAPs regulate microtubule stability 6. Cilia and flagella are highly orders structures made up of microtubules 7. Intermediate filaments (e.g. keratin) provide structural support 8. Microfilaments are made up of actin, which polymerize in an ATPdependent manner 9. The myosin motor controls movement of actin filaments...
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