Lecture 7--cell motility

Vignjevic d kojima s aratyn y danciu o svitkina t

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Unformatted text preview: 63-75. The Role of Fascin in Filopodial protrusion Role of fascin in filopodial protrusion. Vignjevic D, Kojima S, Aratyn Y, Danciu O, Svitkina T, Borisy GG. J Cell Biol. 174(6):863-75. Actin filaments in migrating mcells: lammelipodia and filopodia The organization of actin fibers varies significantly in different areas of the cell. 22 Rho family GTPases promote different kinds of actin structures Rho family GTPases respond to extracellular signals and affect the actin cytoskeleton by regulating actin binding proteins In fibroblasts each Rho family member can respond to distinct upstream stimuli Van Aelst L, D'Souza-Schorey C. 1997. Rho GTPases and signaling networks. Genes Dev. 15;11(18):2295-322. Rho family GTPases the actin cytoskeleton by regulating actin binding proteins Van Aelst L, D'Souza-Schorey C. 1997. Rho GTPases and signaling networks. Genes Dev. 15;11(18):2295-322. Rho family GTPases respond to extracellular signals and affect the actin cytoskeleton by regulating actin binding proteins Rho family GTPases promote different kinds of actin structures Rho Rac Cdc42 Myosin Actin stress fibers Contractility Microtubule stability gene expression Cell cycle Cell migration Actin polymerization Cell spreading Membr. trafficking Gene expression Cell cycle apoptosis Actin polymerization Cell polarity Migration Gene expression Cell cycle apoptosis Cell motility summary 1. Actin contraction underlies coordinated tissue movements, such as neural tube formation and extrusion of cells from epithelia 2. Actin filaments create cell protrusions such as filopodia and lamellopodia at the leading edge of migrating cells 3. Stress fibers consist of myosin and actin filaments and provide tension for contraction and migration 4. Treadmilling of actin molecules makes filaments dynamic 5. Many actin binding proteins regulate actin dynamics: 6. ADF/Cofilin and profilin increase actin dynamics 7. Arp2/3 nucleates branched filaments 8. WASP activates Arp2/3 in response to extracellular cues 9. Bundling proteins and nucleating proteins promote filopodia 10. Rho GTPases regulate the formation of diverse actin-based structures...
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.

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