Lecture 7--cell motility

Wasp in immune system organization and function nat

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Unformatted text preview: ol 2(9): 635-46. WASp family proteins respond to extracellular signals to activate Arp2/3 doamins responsive to signaling factors; when no signals, WAS bends over itself and inhibits its own ARP 2/3 binding domain--> inactivated Inactive WASp does not interact with Arp2/3 Thrasher AJ (2002). WASp in immune-system organization and function. Nat Rev Immunol 2(9): 635-46. WASp family proteins respond to extracellular signals to activate Arp2/3 signal comes around, relieves autoinhibition, opens up WASp, ARP2/3 active domain accessible and ARP2/3 can bind and lead to polymerization In the presence of a signal, WASp interacts with and activates Arp2/3 to promote actin polymerization Thrasher AJ (2002). WASp in immune-system organization and function. Nat Rev Immunol 2(9): 635-46. WASp is activated by signals at the leading edge and recruits Arp2/3 complex WASp is activated by signals at the leading edge and recruits Arp2/3 complex bascterial protein; The bacterial protein ActA recruits Arp2/3 to propel listeria one aspect of its life listeria through cells style is it likes to go inside the eukaryotic cells and swim in them; it can swim in cell by polymerizing actin behind it; made a protein called ActA, and it is a ARP2/3 binding protine similar to Wasp, puts it on its cell while in membrane an that activates ARP2/3 and causes it to be able to move very fast; The bacterial protein ActA recruits Arp2/3 to propel listeria through cells The bacterial protein ActA recruits Arp2/3 to propel listeria through cells stress fibers, going across the cell cells that hav e figured out how to exploit eukaryotic machinery to move around; Actin Dynamics 31 Actin filaments in migrating cells: lamellipodia and filopodia The organization of actin fibers varies significantly in different areas of the cell. 22 Actin filaments in migrating cells: lamellipodia and filopodia Lamellipodia in skin cells migrating on a glass coverslip Filopodia on the surface of a HeLa cell Actin filaments in migrating cells: lamellipodia and filopodia Lamellipodia in skin cells migrating on a glass coverslip Filopodia on the surface of a HeLa cell Actin filaments in migrating cells: lamellipodia and filopodia Lamellipodia in skin cells migrating on a glass coverslip Filopodia on the surface of a HeLa cell Parallel actin fibers are bundled in filopodia Zebrafish sensory axons growing and branching in the skin during development Sandra Rieger Zebrafish sensory axons growing and branching in the sk...
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