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Lecture 7--cell motility

Development sandra rieger zebrash sensory axons

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Unformatted text preview: in during development Sandra Rieger Zebrafish neural crest cells have many filopodia as they migrate Contact inhibition of locomotion in vivo controls neural crest directional migration. CarmonaFontaine C, Matthews HK, Kuriyama S, Moreno M, Dunn GA, Parsons M, Stern CD, Mayor R. Nature. 2008 Dec 18;456(7224):957-61. Zebrafish neural crest cells have many filopodia as they migrate Contact inhibition of locomotion in vivo controls neural crest directional migration. CarmonaFontaine C, Matthews HK, Kuriyama S, Moreno M, Dunn GA, Parsons M, Stern CD, Mayor R. Nature. 2008 Dec 18;456(7224):957-61. Growth of Filopodia nucleation complex at the plasma membrane A protein complex called the “tip complex” nucleates actin filaments on the inner face of the plasma membrane. Growth of these actin filaments drives the plasma membrane outward to form a filopodium. Growth of Filopodia Assembly of the filopodial bundle occurs at the tip, similar to how the tower is built. As a result, the history of the construction is imprinted in the design of the structure allowing [us] to understand how the filopodium was built. --T. Svitkina Growth of Filopodia Formin is an actin nucleator found in the tip complex of filopodia. Unlike the Arp2/3 complex, formin promotes nucleation and growth of unbranched actin filaments Growth of Filopodia Bundling proteins, like fascin, help keep actin filaments parallel in a filopodium The Role of Fascin in Filopodial protrusion Fascin Knockdown Fascin Knockdown WT WT Knocking Down Fascin reduces filopodia Role of fascin in filopodial protrusion. Vignjevic D, Kojima S, Aratyn Y, Danciu O, Svitkina T, Borisy GG. J Cell Biol. 174(6):863-75. The Role of Fascin in Filopodial protrusion Activated Fascin Inactive Fascin Overexpressing activated fascin increases filopodial number, length, and bundling. Activated Fascin Inactive Fascin Role of fascin in filopodial protrusion. Vignjevic D, Kojima S, Aratyn Y, Danciu O, Svitkina T, Borisy GG. J Cell Biol. 174(6):8...
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