Lecture 8--intracellular transport

An mtoc can form without centrosomes centrosome is

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Unformatted text preview: somes centrosome is not the only place gamma tubulin is, this ogrganization is intrinsic to proteins that interact with microtubules. end up with a bit of cell without nucleus and has microtubulues. piece of cell can reorganize so that the microtubules face outside. somehow all the gamma tubulin that was found here was able to reorganize into one cohesive into a microtuble center . Figure 16-33 Molecular Biology of the Cell (© Garland Science 2008) Microtubules provide tracks for movement of vesicles along the axon no growth cone, instead the axon terminal where it synapses - ends of microtubules are at cell body and + ends at microtubule towards + is anterograde transportation _ end retrograde How are molecules transported in the cell? Membrane-bound vesicles and proteins are transported many micrometers along well defined routes and delivered to specific “addresses” Rapid transport (~3µm/s) ~250mm/day Slow transport ~1mm/day Anterograde transport towards synapse Retrograde transport towards cell body 1985: Ron Vale, Mike Sheetz, Bruce Schnapp and Tom Reese discover kinesin at the Woods Hole Marine Biological lab by studying transport of vesicles in the squid giant axon Axonal transport can be reconstituted in vitro Extruded axoplasm assays - Cytosol is squeezed from the axon with a roller onto a glass coverslip. Vesicle movement in this syste...
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.

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