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Lecture 8--intracellular transport

Large globular head binds microtubules and atp 2

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Unformatted text preview: ules and ATP 2. Stalk 3. Small globular head: Binds to vesicles via adaptors Kinesins are a large family; each member has specialized roles in the cell Kinesin superfamily motor proteins and intracellular transport. Hirokawa N, Noda Y, Tanaka Y, Niwa S. Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. Kinesin movement is ATP-dependent Kinesin families Catastrophe Backwards Traffic control: regulation of kinesin motors. Verhey KJ, Hammond JW. Nat Rev Mol Cell Biol. 2009 Nov;10(11):765-77. Figure 16-62 Molecular Biology of the Cell (© Garland Science 2008) Kinesin processivity 1. Kinesin head contains ADP before binding to microtubule 2. Microtubule binding causes ADP release and replacement with ATP 3. ATP binding causes neck linker to bind to catalytic core, throwing the other head forward 4. Trailing head hydrolyzes ATP, releasing phosphate, and the neck attachment 5. Leading head exchanges ADP for ATP and the cycle resumes. Animation of kinesin dynamics Ron Vale lab Animation of kinesin dynamics Ron Vale lab Molecular structure of dyneins kinesin dynein Dyneins - composed of 2-3 heavy chains with total MW of 1,000kD and several light chains Like Kinesins, Dyneins use ATP to move processively along microtubules Two major families of dyneins Figure 16-59 Molecular Biology of the Cell (© Garland Science 2008) Cytoplasmic Dynein Ron Vale lab Basic Structure of Cilia and Flagella Nexin Inner dynein Bridge connecting central singlets Plasma membrane Outer dynein arm Central p...
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