Lecture 8--intracellular transport

Pc is pericentriolar material microtubules are

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Unformatted text preview: for separation of chromatids during mitosis Dynamic instability of microtubules increases during mitosis - lifetime interphase - 10min - lifetime mitosis - 30sec mitosis interphase Dynein contributes to the centrosome movement and spindle orientation Microtubule dynamics and motor proteins are required for mitosis Ron Vale lab Microtubule dynamics and motor proteins are required for mitosis Ron Vale lab Microtubule dynamics and motor proteins are required for mitosis Ron Vale lab Microtubule dynamics and motor proteins are required for mitosis Ron Vale lab Intracellular transport summary 1. Transport along actin filaments is mediated by myosin motors 2. Microtubules consist of 13 protofilaments made up of tubulin dimers, which are added to the plus end in the GTP-bound state 3. Microtubules undergo cycles of catastrophe and growth: dynamic instability 4. Microtubules are nucleated by gamma tubulin and emanate from Microtubule Organizing Centers (MTOCs) 5. Characterization of axonal transport led to the discovery of microtubule-based transport 6. Transport along MTs is mediated by motor proteins: Kinesins move towards the plus end and dyneins towards the minus end 7. Cycles of ATP binding regulate motor protein movement 8. In addition to transport, microtubule motors are required for cilia movement, organelle positioning and mitosis...
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