Lecture 8--intracellular transport

Vale rd reese ts sheetz mp cell 1985 aug42139 50

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Unformatted text preview: 1985 Aug;42(1):39-50. Purification of the axoplasmic factor that supports axonal transport on microtubules Kinesin! Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Vale RD, Reese TS, Sheetz MP. Cell. 1985 Aug;42(1):39-50. Movement on Microtubules Requires Motor Proteins • Progression of organelles along axons requires microtubules and the motor proteins: kinesin and dynein. Other processes dependent on motor proteins: • Transport of vesicles for exocytosis/endocytosis or between the endoplasmic reticulum and Golgi • Extension of the endoplasmic reticulum • Integrity and reassembly of the Golgi apparatus A single microtubule can support bidirectional movement Single microtubules from squid axoplasm support bidirectional movement of organelles. Schnapp BJ, Vale RD, Sheetz MP, Reese TS. Cell. 1985 Feb;40(2):455-62. Dyneins and kinesins travel in opposite directions and move along individual protofilaments Kinesin-14 is the exception to the rule: It travels towards the - end Kinesin 14 Figure 16-63 Molecular Biology of the Cell (© Garland Science 2008) Kinesin Tetramer: Two heavy chains and two light chains, ~380kD Three domains 1. Large globular head: Binds microtub...
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